(NEXSTAR) — Actor Louise Fletcher, best known for her role as Nurse Ratched in the 1975 Milos Forman film “One Flew Over the Cuckoo’s Nest” died Friday of natural causes, her representatives told several outlets.

Fletcher’s son Andrew Bick confirmed to the Hollywood Reporter that the 88 year-old died in her Montdurausse, France, home. Fletcher, who won an Academy Award for her “Cuckoo’s Nest” role, previously battled breast cancer, THR reports.

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The decorated actor, an Alabama native, had a career spanning back to the 1950s. In addition to film, Fletcher’s TV work included roles on “Star Trek: Deep Space Nine,” “The Twilight Zone” and “Shameless.”

Her portrayal of the sadistic Ratched, opposite Jack Nicholson, continued to be her most acclaimed until her death. The film, based on Ken Kesey’s 1962 novel, won all five major Academy Awards after its release — including an Oscar for Nicholson and the Best Picture trophy.

Fletcher was born July, 22, 1934 and was married to Jerry Bick from 1960 to 1977. She is survived by two children.

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